How do antidepressants work? – Neil R. Jeyasingam

Dig into the discovery of antidepressant drugs, how they work, and what we still don’t know about depression.

In the 1950s, the discovery of two new drugs sparked what would become a multi-billion dollar market for antidepressants. Neither drug was intended to treat depression at all— many doctors and scientists believed psychotherapy was the only approach to treatment. Neil R. Jeyasingam details the decades-long journey that followed and how it revolutionized our understanding of depression.

Lesson by Neil R. Jeyasingam, directed by Skirmanta Jakaitė, Art Shot.

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  1. Patricia Angustia on March 27, 2021 at 9:18 pm

    I remembered when I was about to get a prescription for taking up antidepressants and my mom goes hysterical about it because she fears this psychedelic effects, and some sort of irrational fear that I might go insane or will worsen me and instead just says: "You don’t have enough spirituality on you" or like "God is not present enough in your life" or like "You’re just adding up more financial burden for me" and some other hurtful ridiculing things she’ll say and often I don’t speak about it. I’m in an Asian household and have been dealing with depression and anxiety that I have been battling for a very long time. I tried asking for help about my mental health and usually the result in the end is just that I’m being a clown to them anyway so, yeah. Thank you for reading.

  2. ICSE,CBSE PREP on March 27, 2021 at 9:18 pm


  3. Feer O on March 27, 2021 at 9:18 pm

    i believe everyone always feel sad but i dont think all of them have depression

  4. Sakura Nova Ryan on March 27, 2021 at 9:21 pm

    The amount of relief I had when I heard the word chemical imbalance. All this time I had been blaming myself. Listening to people saying it’s my fault that I am weak or that I don’t try to be happy. Or that it’s cause intentionally be sad to grab attention. It’s been suffocating me. But the idea that all along it might have not been entirely my fault. That all my attempts and trying to be better to act happier or just suppress my depression wasn’t for nothing. I am real. My depression is real. And it’s treatable. I feel better.

  5. David D on March 27, 2021 at 9:25 pm

    My phone is listening to me. This is now clear

  6. Katherine on March 27, 2021 at 9:28 pm

    I love these little people they’re so cute

  7. Skye Blue on March 27, 2021 at 9:29 pm

    Funny how the test for depression still is: Are you depressed?
    Not being insensitive but just coming from experience from friends and classmates that the protocol to get these drugs is to merely claim yourself as depressed. Depression is real but stigma would be dismissed if it was more scientifically diagnosed.
    (Also I’m a biomedical science major so I understand brain chemical imbalances is a credible argument just wish it was more rigorously diagnosed)

  8. Brendan Forde on March 27, 2021 at 9:31 pm

    thanks for reminding me to take my meds <3

  9. lithiumkid on March 27, 2021 at 9:35 pm

    i really wish the chemical imbalance theory hadn’t become this big.

    been depressed since 11, tried a million antidepressants, none’s benefits – if any existed – outweighed the side effects. side effects that always just further complicated the process of getting better.

  10. Henk - on March 27, 2021 at 9:35 pm

    Lots of self proclaimed ‘experts’ in the comment section here…

  11. DragonKazooie89 on March 27, 2021 at 9:36 pm

    I take Zoloft but for anxiety related to ASD, not depression

  12. zubair hasany on March 27, 2021 at 9:37 pm

    I came here for prozac

  13. Mário on March 27, 2021 at 9:37 pm

    salve salve família

  14. Nguyen Minh on March 27, 2021 at 9:39 pm

    Antidepressants_ do you mean wine and coffee?

  15. XD gaming on March 27, 2021 at 9:40 pm

    pov you have depression and u foud out in the video that one drug can cure it

    you: :0

  16. The Epic Man fourtwenty on March 27, 2021 at 9:40 pm

    Antidepressants cure influenza!!!!!!!!!!!!! I gave it to my children and he was fine!!!!!!!!

  17. Dr Science on March 27, 2021 at 9:41 pm

    Crazy how today I saw this, and today I also got started on antidepressants

  18. Cosmonauta Fantasmal on March 27, 2021 at 9:41 pm

    I’ve been taking Fluoxetine like for 5 years… I’m doing well but I think I need psychotherapy to end this fkn depression and anxiety disorder finally. Or I don’t know I can be cured. 🤔😴

  19. Makkusu Otaku on March 27, 2021 at 9:43 pm

    Dude, the animation…….

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  21. Lea Alarde on March 27, 2021 at 9:44 pm

    This is so timely. I was just prescribed with fluoxotine last February for my anxiety. But not prozac but motivest

  22. ahmetsercan soydan on March 27, 2021 at 9:44 pm

    Short answer they do not. Muster some power and cut the toxic people and places off your life.

  23. Tree Lord on March 27, 2021 at 9:52 pm

    As someone who was put on Prozac/fluoxetine at a young age when it wasn’t needed, I very strongly feel the need to point out that being forced to take it is what originally caused me to start having suicidal thoughts.

    Every hospital I’ve been to doesn’t really give a damn about the kids and will force me to take it even though I’ve told them why I stopped. If I don’t willingly take it they’ll hold down and inject it onto me.

  24. King Tito on March 27, 2021 at 9:53 pm

    Crypto Investment is the best

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    Wow, Crypto investment really pays

  26. Tyler Kelley on March 27, 2021 at 9:55 pm

    Successful people don’t become that way overnight. What most people see at a glance-wealth, a great career, purpose is the result of hard work and hustle over time. I pray that anyone reading this will be successful in life.

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    It is batter if it have chinese☹️

  29. Dizel live on March 27, 2021 at 9:57 pm

    How do antidepressants work?

    -They don’t.

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  32. STEPHANIE ESQUIVIAS (Student) on March 27, 2021 at 9:59 pm

    I swear I learn more on youtube than at school

  33. Aidan on March 27, 2021 at 10:01 pm

    Not going to lie… I didn’t learn anything useful from this video

  34. Celestia C. on March 27, 2021 at 10:01 pm

    did anyone notice how 3:13 kind of references the queen’s gambit? the pills also resemble the ones beth harmon used to take

  35. KAĞAN NASUHBEYOĞLU on March 27, 2021 at 10:03 pm


  36. 편경훈 on March 27, 2021 at 10:05 pm

    사회가 점점 개인화되고 단체 보다는 개인을 중요시 하게 되면서 우울증에 걸린 많은 사람들이 생겨나는 것 같습니다. 항우울제가 궁극적인 치료제가 될 수는 없겠지만 이를 발판삼아 많은 사람들이 우울증을 극복했으면 합니다.

  37. 엄. on March 27, 2021 at 10:05 pm

    antidepressants saved my life.

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  39. Vismay Agrawal on March 27, 2021 at 10:06 pm

    This video should have talked about psychedelics too.

  40. Khassara Ennis on March 27, 2021 at 10:07 pm

    Mm mm don’t do it USAA!

  41. Read my ABOUT section PLEASE on March 27, 2021 at 10:09 pm

    Sorry for this comment. I’m not a bad person, just a desperate one. Lost so much since 2020. 💔 Have a spare $1? Saving to get a working laptop (for homebased job). Got no opportunities outside, Covid cases got worse here. 😷

  42. Guru Notebooks on March 27, 2021 at 10:09 pm

    The mindfulness book "30 Days to Reduce Depression" by Harper Daniels is a great resource.

  43. Jasmine Adams on March 27, 2021 at 10:10 pm

    this artist is incredible!!

  44. Murat on March 27, 2021 at 10:11 pm

    The animations are awesome.

  45. mateussm britanic on March 27, 2021 at 10:11 pm

    I miss ethical dillema videos…

  46. jackstone112 on March 27, 2021 at 10:12 pm

    doggos cure depression!

  47. Alparslan Korkmaz on March 27, 2021 at 10:12 pm

    Nice video.

  48. Just Dashie on March 27, 2021 at 10:12 pm

    Something I hate about antidepressants is it’s sometimes treated as a "quick fix". But it’s not a long term solution.

  49. bladi LAC on March 27, 2021 at 10:13 pm

    My friend is diagnosed with clinical depression but she’s not taking any meds because she doesn’t have the money for it due to quarantine. She didn’t want to ask her parents for the money. I offered her help but she refused. What should I do here?

  50. Englisholic Expressions on March 27, 2021 at 10:16 pm

    Ssri works but with combination of other drugs like benzo otherwise it’s difficult to tolerate it.

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